「チーム猶興」３位入賞 ! ! おめでとう～☆☆
日時：平成２０年７月２９日（火）
会場：東京体育館メインアリーナ
九州沖縄代表として出場した猶興館高校女子の体操同好会「チーム猶興」の１２名はヒップホップスモール部門 で三位入賞。
参加校の殆どが部活動として出場している中 同好会の「チーム猶興」はとても堂々とした演技で立派でした。
東京支部の岩崎、小菅両副会長と伊崎満雄(s35年卒)さんの３人で応援してきました。
“ミスダンスドリルチーム 日本大会２００８”に2,651件のコメントがあります。
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The first investigation of the in vitro efficacy of plant extracts against HP was printed in 1991
. This group reported that extracts of 13 Malagasy medicinal plants were
effective against numerous scientific strains of HP in vitro.
In 1996, Fabry and colleagues reported that a variety of East African medicinal plant
extracts had inhibitory effects on the growth of HP in vitro .
One plant, Terminalia spinosa was reported to be probably the most energetic, with an MIC
vary 62.5-500 mg/ml. Extracts of Thymus vulgaris and Cinnamonum zeylanicum have been additionally reported to inhibit the
expansion of the bacterium at concentrations of3.5 mg/ml .
In 1997, investigators found that frequent meals vegetation such as garlic, soybean and fresh greens may be protective towards HP
infections [seventy eight-79].
104 The pressure was isolated from homogenates
of a sponge belonging to the genus Microomnospora.
The macrolide confirmed a very robust cytotoxic activity in opposition to P-388, and low but important activity in opposition to A-549,
HT-29, and MEL-28 cell lines; it confirmed antibiotic exercise in opposition to Micrococcus luteus as nicely.
Chemical Constituents Of The Family Mycalidae
Similar variation within the content material of three-APs has been detected even within a single sponge species collected from totally different geographical areas , suggesting that the
surroundings can affect their secondary metabolism. The majority of pure
3-APs isolated so far are monomeric compounds differing in the size,
saturation, branching and termination of the alkyl chains.
These compounds usually present cytotoxic and/or antibacterial actions at
concentrations of some micrograms per mL. A smaller variety of
oligomeric and polymeric three-APs have also been isolated and partially characterised.
It is clearly evident that polymeric 3APs exert many
more various and potent biological actions. Most of the 3-APs that have been isolated to date are listed in accordance with
their primary structural types.
Recently, two new non-sulfated hexoglycosides, parvimosides A (57!)
and B , Fig. had been isolated from the sea cucumber Stichopus parvimensis .
Holothurin 57f is said to holotoxin B, the difference being the absence of
a double bond at place 25 within the aglycone of parvimoside
A (fifty seven!). On the other hand, parvimoside B is the 25-dihydroderivative of holotoxin B] .
values of3.9 and 10.3 nM towards KB and LoVo cell lines respectively.
It required a higher concentration than dolastatin 10 to disrupt microtubules for its weaker in vitro cytotoxicity.
The acyclic peptide tasiamide 139 was isolated from the marine cyanobacterium Symploca
Sp.97 collected at Short Drop-off in Palau. Tasiamide was
cytotoxic towards KB and LoVo cells with IC so values of 0.forty eight and
three.4711g mL- 1, respectively.
Further evaluation of the zootoxicities of the holothurins 57d and 57e and their desulfated analog using the brine shrimp (Artemia salina L.) larvae mortality bioassay confirmed that
hemoiedemoside A had a noteworthy toxicity (LC so 18.7 ppm).
Hemoiedemoside B was 2 times less energetic (LC so 47.5 ppm) than 57d and nearly 10 times more energetic than the desulfated by-product (LC so 424.5 ppm).
Thus sea cucumber glycosides are strong however not absolute defenses
against various predators. Glycosides of sea cucumbers
can inhibit the growth of larvae of marine organisms,
significantly sea-urchin embryos, containing ldl cholesterol in the cell membranes .
Sea cucumbers and sea urchins occupy fairly different niches as Levin accurately noted, and aren’t opponents .
Therefore, it’s not appropriate to attribute inhibition of sea-urchin improvement as
a specific function of glycosides. However, seaurchin embryos could also be an excellent model for investigation of allelopathic motion of sea cucumber glycosides.
The glycosides of Cucumaria echinata demonstrated an motion on shellfish
in culture . Sea cucumber glycosides may play an important function in defending
the physique floor from fouling by other organisms.
Extracts with an MIC of one hundred.zero ~g/ml included Pouzolzia pentandra , Cycas siamensis , Litsea elliptica and Melaleuca
quinquenervia . Ginger root , a plant well-known worldwide
to treat gastrointestinal ailments additionally has activity
in opposition to HP . Methanol extracts of ginger rhizome inhibited the growth of 19 HP strains in vitro with a
minimal inhibitory concentration range of 6.25-50 ~g/ml.
6, all had various levels of exercise, with an MIC vary of 0.78 to 12.5 ~g/ml and apparently
had vital exercise against the cagA+ strains . Cytotoxic exercise of 3-alkylpyridine and
three-alkylpyridinium compounds from marine sponges on different cell strains.
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An aqueous extract of garlic inhibited the growth of HP strains at concentrations of
forty Jlg/ml . Rabdosia trichocarpa, a conventional remedy for gastric and stomachic complaints
in Japan, was additionally inhibits the growth of HP in vitro
. A diterpene named trichorabdal A, isolated from the plant
confirmed very strong in vitro antibacterial exercise in opposition to
HP, as properly . In 1999, the anti-HP results of seven Turkish plant extracts, used in folk medicine for the remedy of gastric
illnesses together with peptic ulcers, was reported . Extracts of the flowers of Cistus laurifolius, cones of Cedrus
libani, aerial components of Centaurea solstitialis ssp.
solstitialis, fruits of Momordica charantia, aerial components of Sambucus ebulus, and flowering herbs of Hypericum perforatum were energetic with an MIC
range of between 1.ninety five and 250 mg/ml . In 2003, a screening of 20 plant extracts from Thailand used
to treat gastrointestinal ailments reported that over 50% of the plant
species tested had anti-HP activity .
Research In Natural Products Chemistry: Bioactive Pure Products Part
L
Betancour et al. reported for the first time the antiherpetic exercise of a sequence of sponge-derived diterpenes.
A family of thirteen new diterpene glycosides, pseudopterosins P-Z, Fig.
, and secopseudopterosins H and I even have been isolated from two collections of the
marine sponge Pseudopterogorgia elisabethae from the Southwestern Caribbean sea in Colombia .
Pseudopterosin P displayed strong antiviral exercise towards HSV-l,
HSV-2 and VZV. have additionally been isolated from the blue coral Heliopora coerulea .
Helioporins A and B showed antiviral activity against HSV-l.
Comin et al. isolated disulphated polyhydroxysteroids with inhibitory impact on the replication of HSV-2
from the Antarctic ophiuroid Astrotoma agassizii.
However, it is our belief that ALL-1 may not symbolize a unique complicated.
Apparently, all these elements were discovered to coexist at the
promoter of the HoxA9 gene in vivo .
The ALL-1/MLL-1 proteins operate in transcriptional activation as ALL-1 to methylate lysine-4
of histone H3, which is understood to be involved in transcription exercise .
The putative ALL-1 complicated additionally included subunits of the
RNA polymerase II-related TFIID advanced, as well as subunits of the chromatin transforming complexes SNF2h, Swi/Snf, NuRD,
and Sin3.
From the info reported up to now, we cannot
exclude the chance that this group of distinct, however functionally associated, complexes associate transiently,
quite than as a biochemically secure entity in the cell.
The presence of HDACs is according to the need to deacetylate particular residues in histone H3 for his or her subsequent methylation.
On the other hand, hemoiedemoside B was much less lively that 57d.
These outcomes suggest that both the structure of the triterpenoidal aglycone and
the presence and number of the sulfate teams on the oligosaccharide chain might play
a significant function within the antifungal exercise of those
saponins.
more energetic than cucumarioside A whereas cucumarioside G j was
not active in the identical assay. Two trisulfated tetrasaccharide
glycosides, liouvillosides A and B isolated from the Antarctic sea cucumber Staurocucumis liouvillei have
been discovered to be antiviral against herpes simplex virus sort I (HSV-1) at
concentrations under 10 I-lg/ml. Glycoside 89 is
distinguished from 88 only by the absence of a 24-double bond within the aspect chain of the aglycon .
Chemical And Organic Aspects Of Marine Sponges From
The Household Mycalidae
The crude aqueous extract from the leaves of Helichrysum litoreum at
a concentration of 1.35 mg/ml showed important antiviral activity on HSV-1 in human lung fibroblasts, as demonstrated by
the absence of cytopathic effect . Baccharis dracunculifolia DC
from the genus Baccharis, is a native plant from Brazil, and the most important botanical origin for the production of inexperienced propolis by honeybees.
Propolis and plant secretions are derived from three species most regularly
mentioned as botanical sources of the bee glue in Brazil, including
Baccharis dracunculifolia . Recently, Leitao et al.
demonstrated that extracts of this plant produced a basteriostatic impact on Streptococcus mutans cultures.
33 Structures of trapoxins A and B Enamidonin Enamidonin was discovered by Koshino et al.
in 1995, from Streptomyces sp. throughout screening for inhibitors of the mitogenic
exercise of epidermal progress factor. Enamidonin inhibits epidermal development issue-dependent uptake of 3H-thymidine into Balb/MK cells with an IC so of 10llg/ml.
This compound reverses the transformed morphology of src-ts-NRK to the
normal flat morphology with an ED so of 101lg/ml.
The anti-herpes simplex virus kind I (HSV-l) activity of diethyl ether
extract from the flowering tops of this plant had been additionally investigated .
The extract showed important antiviral exercise at concentrations starting from four hundred to a hundred flg/ml.
within the forthcoming structure elucidation of such advanced lessons of compounds.
Finally, the supra-molecular construction of poly-APS has been also studied by dynamic light scattering
measurements. These data counsel that in aqueous answer poly-APS are mainly organized as noncovalently certain aggregates,
an interesting feature which could be liable for the wide range of organic actions reported on these
compounds . chemical markers for the systematic willpower of haplosclerid sponges .
However, not all such sponges comprise 3-AP
compounds. For instance, only one species of Haliclona out
of 5 collected within the Adriatic Sea contained three-APs (T.
Turk, unpublished information).
with an amino, N-methoxylamine, or oxime methyl ether performance on the end of the alkyl chain have
been subsequently purified . Assuming the gross construction of niphatesine D to have been accurately assigned,
Romeril et al. forged doubts on the right assignment of the S-absolute stereochemistry of 6 primarily based on optical
rotation. The stereochemistry was first assigned by
Rao and Reddy by the synthesis of6 after which confirmed by Bracher and Papke .
on the tested concentrations (l.5-50 /-lg/spot), whereas patagonicoside A was
much less energetic (eight-19 mm) at the similar concentrations.
These results correlated with the info on antifungal activity.
Most of the members of the Stichopodidae family (Stichopus japonica ,
Stichopus chloronotus , Parastichopus californius and Bohadschia bivittata ) have been proven to provide hexosides as main components of the glycosidic fraction. They
are non-sulfated glycosides with a linear three-zero-Me-Glc-(l
3 three)-G1c-(l4 four)-Xyl chain and a branching of a linear trisaccharide at C-2 of
the xylose unit. The solely examples with a glucose unit as an alternative of the terminal three-zero-Me-glucose are holotoxin B] and B .
Propolis samples collected within the dry and rainy season from an experimental apiary positioned in cerrado
vegetation in Brazil were investigated by Santos et al.
. Antibacterial assays were performed by the tactic of dilution of an ethanol extract of propolis in agar, and confirmed that all sixteen actinomycete strains examined had been inhibited
by propolis concentrations of 0.1 to zero.25%.
Regarding antibacterial exercise, each extracts of Baccharis grisebachii had been lively on methicillin-resistant and methicillinsensitive
Staphylococcus aureus, with minimum inhibitory concentrations from one hundred twenty five to 500 flg/ml.
Fungicidal exercise of wild vegetation rising in Mexico was evaluated in opposition to the mould
species Aspergillus jlavus, Aspergillus niger, Penicillium chrysogenum,
Penicillium expansum, Fusarium moniliforme and Fusarium poae .
Two mould species had been managed by Baccharis glutinosa Pers.
Other Baccharis species with antiviral properties additionally included Baccharis teindalensis
L. that some plant-based medicines would have exercise against HP in vitro.
To verify this operate, Levin noted surfaces of most sea
cucumbers are not fouled but Psolus species, coated
with overlapping calcareous plates have only
slightly toxic glycosides and fairly often are
fouled with sponges, algae and so forth.
The high antifungal activity of sea cucumber glycosides may provide a protecting
motion against some fungi. Apparently biological capabilities of
triterpene glycosides, which initially were solely regulatory ones,
later became broader. Therefore, external functions have
appeared as a secondary evolutionary response of sea cucumbers to fish predation .
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Another structural feature in three~-hydroxyholost-9-ene
aglycones is the presence of a 12a-hydroxyl group, similar to within the hexaglycoside bivittoside
D , Fig. Bivittoside D, widespread in sea cucumbers belonging to the genus Bohadschia was
described by Hedge et al. as a brand new compound in the sea cucumber identified
as Telenata ananas. Kalinin et al. considered that this taxonomic classification relates to Thelenota ananas
for the reason that genus Telenata has by no means been described for
sea cucumbers. A novel bioactive macrolide, IB , was isolated from
the fermentation broth of a marine actinomycete, L-25-ES20-008.
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